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and (4) activated protein kinase C-mediated cell-signaling cascade, eventually leading to an increase in liver cell apoptosis (2)

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The KDIGO CKD-MBD guideline of 2009 (276) and its subsequent updates in 2017/2018 and 2025 (277-279) suggest maintaining iPTH levels in CKD stage 5D patients (i.e

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