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However, as noted by the Alzheimers Drug Discovery Foundation (ADDF), virtually all trials involving epithalon have been conducted in Russia and have yet to be independently confirmed [5]

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Protofibrils of amyloid beta have been deemed the main drivers of AD where they result in disruption of membrane integrity and cause synaptic toxicity, and therefore drugs like Aducanumab and Lecanemab that target the protofibrils are deemed disease modifying [313]

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