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Novo Nordisk Patients Seeking Upgrade CagriSema Patients already on semaglutide (Wegovy) who need greater weight loss can potentially upgrade to CagriSema within the Novo Nordisk ecosystem once approved, leveraging the same GLP-1 component plus added amylin agonism

Consistent frequency matters more than any single dose optimization

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Indeed, prior studies have suggested that the desialylated as-APF peptide may occur naturally, and structureactivity studies found that APF peptide derivatives truncated at either the N- or C-terminus retain high biological activity 27,30,62,63

This is theoretically sound but clinically unproven