Because administered doses were not identical across all arms, primary comparisons were performed using both as-dosed baseline-adjusted parameters and dose-normalized baseline-adjusted parameters (e.g., iAUC 024 per mg and C max per mg)
While this reduction was significant, Kushner said the trial also included a number of caveats
Novo said Lilly acknowledges the existence of that high-dose Wegovy in a "small footnote," but called it "ambiguous, confusing, virtually illegible, and wholly inadequate," as it does not communicate that it is significantly more effective than the lower doses of the drug
Starting with lower doses, titrating slowly, and maintaining regular medical supervision minimize these risks
Partnering with your healthcare team Deciding whether to keep taking or stop semaglutide is something you and your doctor should decide together