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TABLE 2 Different types of pesticides to the neurodegenerations risk for human (modified from Kori et al., 2018)

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 35% by weight of the cholesterol

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Step 3: MTHF releases its methyl group via vitamin B12 to the methionine cycle, which produces THF again and restarts the cycle

Additionally, optimizing dosing schedules and timing in combination regimens can maximize therapeutic efficacy while minimizing toxicity to normal tissues