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Human oocytes, which stay for a long time in prophase I of meiosis, can accumulate oxidative damage [34,35,36], leading to a gradual decline in oocyte quality with advancing maternal age (Fig

Thus, the relationship between insulin and IGFBP-I is inverse (34), where IGFBP-1 is low during states of hyperinsulinemia but elevated during states of hypoinsulinemia (35)

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In contrast, there was minimal change in the group treated with laser alone (808 nm, 1 W/cm 2 ) and PDA, whereas ROS levels were reduced in the PDA@Pt groups

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