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The triple therapy of metformin, a DPP-4 inhibitor and a SGLT-2 inhibitor has a very low treatment related hypoglycaemia risk, leads to a further, almost additive reduction of glycaemic parameters, a body weight loss in the same range as with a mono- or dual therapy with a SGLT-2 inhibitor and also to the expected SGLT-2 inhibitor induced reduction of blood pressure

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During weight loss, caloric restriction, and reduced physical activity (common during the adjustment period of GLP-1 therapy when patients feel fatigued ), these genes become more active

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