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Why Some Symptoms Improve Faster Than Others Different tissues respond at different rates: The brain responds relatively quickly Thermoregulation stabilizes over weeks Musculoskeletal and metabolic effects take longer This explains why hot flashes may improve before energy or body composition changes are noticeable

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Bone Res 10:60 Mustonen A-M, Malinen M, Paakinaho V, Lehenkari P, Palosaari S, Krj V, Nieminen P (2025) RNA sequencing analysis reveals distinct gene expression patterns in infrapatellar fat pads of patients with end-stage osteoarthritis or rheumatoid arthritis

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