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doi: 10.1002/glia.22389 [DOI] [PMC free article] [PubMed] [Google Scholar] 16

Emerging preclinical/clinical insights into mitochondrial dynamics, m 6 A-mediated transcript regulation, and immunemetabolic signaling in chemoresistant colorectal cancer highlight the translational potential for designing rational synthetic drug scaffolds that modulate validated molecular targets, paving the way for next-generation precision therapeutics

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We know that insulin resistance can hinder weight loss, and there is research from a 2009 study that indicates exercise, carbohydrate moderation, and quality sleep can help reverse insulin levels and pre-diabetes