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Discussion Despite several studies into the biology and genetics of hair greying or canities, the mechanism by which human scalp hairs lose pigmentation remains poorly understood, due in part to the complexity of interaction between different cell types, complex protein interactions, differential gene expression during the hair growth cycle, and variable conditions that occur within the hair follicle microenvironment 1,7,8,9,10,13,41,60,69,70,71,72,73,74
Based on this, rutin can upregulate the cell adhesion molecule-1 (CD31) and vascular endothelial-cadherin (VE-cadherin) expression levels, while downregulating the -SMA and collagen 1 expression levels, alleviating EMT through elevating LC3B II/LC3B I ratio and beclin 1 expression and restoring autophagy in db/db mice and HG-treated GEnC (Dong et al., 2023)
Nutrex Liquid L-Carnitine 3000 Nutrex Liquid L-Carnitine 3000 $19.99 / products.product.pickup_availability.unavailable Your payment information is processed securely
IUBMB Life 71(1):4556
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