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Main text Role of oxidative stress in ALS ALS is an adult-onset neurodegenerative disease, characterized by degeneration and loss of upper motor neurons (MNs) in the cerebral cortex and lower MNs in the brainstem and spinal cord [69], leading to progressive weakness of voluntary muscles, and death caused by a diaphragmatic failure within 25 years [70, 71]

J Transl Med (2019) 171:348

As described by Cant et al

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The larger concern is not riboflavin itself but the full ingredient panel and the temptation to stack multiple products