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Selenoprotein k knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses

This off-target binding is the likely contributor to its cortisol and ACTH co-secretion, as it stimulates the hypothalamic-pituitary-adrenal axis in addition to the GH axis

Overproduction of ROS and abnormal infiltration of immune cells may be involved in lupus nephritis (LN) due to ferroptosis, as suggested by a bioinformatics study that identified eight ferroptosis-related genes (including KRAS , Mapk14 , PIK3CA , EGFR, SRC , mapk3 , ATM and VEG ) that might be promising biomarkers of ferroptosis in LN [163]

Neurosci Lett 193: 2528

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