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However, several drugs, including teprotumumab and BIIB-022, which target IGF-1R, have not shown good therapeutic effects in clinical trials, possibly due to the lack of reliable IGF-1R inhibition biomarkers

J Biol Chem 279(53):5513755146

10.1016/j.atherosclerosis.2012.05.007

The Blunt Truth About Glutathione Reconstitution Here's the honest answer: most people who fail to see results from glutathione therapy didn't receive ineffective medication