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Journal of Generic Medicines, 9 (1), 3-12

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sgRNA (CAGCCAAAATCACAGAATGA) targeting N-terminus of SNIP1 gene was cloned into pX330-BbsI-PITCh (addgene #127875) 121 and microhomology arms surrounding CRISPR-Cas9 cleavage site (each 20 bp long) were introduced into donor plasmid pCRIS-PITChv2-Puro-dTAG (addgene #91793) 71

Due to this potential risk, most prescribers avoid Ozempic in patients with a history of pancreatitis