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"These drugs are thought to work by engaging part of the brain called the hypothalamus, which helps regulate a wide variety of hormones," says Jena Shaw Tronieri, Senior Research Investigator at Penn's Center for Weight and Eating Disorders and a co-author of the study
Krivic et al
MOTS-c activates AMPK by disrupting the folate cycle, specifically by inhibiting AICAR transformylase, an enzyme in the de novo purine synthesis pathway
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