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F-AFE significantly reduced -hexosaminidase release (IC 50 = 30.73 g/mL), TNF- (IC 50 = 46.96 g/mL), and PGE2 (IC 50 = 36.27 g/ml) production by IgE-activated RBL-2H3 mast cells in a noncytotoxic and dose-dependent manner [83]