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This approach reflects the success seen with SGLT2 inhibitors, which have demonstrated significant cardioprotective and anti-inflammatory effects in conditions such as SLE, leading to their integration into clinical practice for autoimmune diseases ( Statements Author contributions GC: Conceptualization, Data curation, Investigation, Methodology, Writing original draft, Writing review & editing

Unlike CagriSema, there is no fixed-dose reference for a cagrilintide + tirzepatide pairing

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However, it is important to note that humans have fewer C-cells and GLP-1 receptors in the thyroid gland compared to rodents, and no C-cell changes have been observed in clinical trials involving patients treated with GLP-1 RAs [26]