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Saigusa D, Motoike IN, Saito S, Zorzi M, Aoki Y, Kitamura H, et al

Animal studies administering 5-Amino-1MQ orally to diet-induced obese mice have shown dose-dependent reductions in body weight (typically 10-30% reduction compared to vehicle-treated obese controls over 4-12 week treatment periods), with the weight loss primarily reflecting fat mass reduction while lean mass is preserved or even increased

Evoked patch pipettes (47 M resistance) were filled with an internal solution containing: 120 mM potassium gluconate, 10 mM KCl, 1 mM MgCl 2 , 0.5 mM EGTA, 40 mM HEPES, and adjusted to pH 7.2 with KOH)