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Am J Kidney Dis 2016: 67: 49-55) This variation between serum markers and measured GFRs appears to be inherent, as shown in plots of eGFR vs measured GFR, whether calculated from serum creatinine or cystatin C [5,6,7,19]

This suggests that the effect involves inhibition of sodium-hydrogen antiporter (NHE3) (33)

Over time, this can contribute to fatigue, constipation or diarrhoea, muscle loss and difficulty maintaining long-term results

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[8] This mechanism makes BioPerine valuable in thermogenic formulas where maximizing absorption of fat-soluble compounds matters