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Behavioral and dietary interventions for weight loss are known to improve psychological well-being, including self-esteem, body image, health-related quality of life, and mental health, suggesting weight loss with GLP-1s may have similar beneficial impacts

The peptide's effects on multiple receptor subtypes account for its range of biological activities observed in research settings

The most productive research direction, based on the current evidence base, involves combining GHK-Cu treatment with multi-omics approaches (transcriptomics, proteomics, and metabolomics) to build a more complete picture of how the compounds gene-level effects translate through the entire cellular response cascade

Interestingly, recent research has highlighted a dual role for Nrf2 in cancer: while basal Nrf2 activity aids normal cell defense, cancer cells can exploit Nrf2 for chemoresistance