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Their lack of selectivity leads to widespread adverse effects such as dry mouth, blurred vision, urinary retention, and severe constipation (fourth panel)

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UCK2 inhibitors are still in preclinical development, but are positioned in combination with 5FU or other cytotoxics that alter nucleotide pools

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J.YangQ.SunW.WoodsS

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Xiaogang Qin, [email protected] These authors have contributed equally to this work This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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