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A selective depletion of mitochondrial GSH by chronic ethanol exposure has been consistently reported 32

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35 There is ample evidence for three infectious agents regarded as autoimmunity triggers in RA, namely Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans (Aa), and Epstein-Barr virus (EBV)

The consumption of salty ultra-processed foods, including fried snacks, pizza, and fast foods, was associated with higher levels of loss of control eating and overeating (125)

This is an essential point to consider when assessing the inter-variability in the response to metformin, as it helps to understand the gut microbiotas contribution to the unresponsiveness