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*Correspondence: Boutaina Daher [email protected] Pouyssgur [email protected] This article was submitted to Cancer Metabolism, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Skin Hydration Glutamic acid contributes to natural moisturizing factors (NMF)

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Phytocompounds like 5-(7a-Isopropenyl-4,5-dimethyl-octahydroinden-4-yl)-3-methyl-pent-2-en-1-ol showed the highest binding affinity (-10.061 Kcal/Mol) with ES1 (pdb id-1A52) and formed two H-bonds at the residues Glutamic acid (GLU) 353 and Arginine (ARG) 394

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