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Ang II treatment reduces the ABCG1 (an important molecule associated with cholesterol homeostasis) expression, and the overexpression of SIRT6 improves Ang II-induced lipid droplet formation, cholesterol accumulation, and cholesterol efflux capacity, restoring ABCG1 expression, further affecting ABCG1-mediated cholesterol efflux to ameliorate Ang II-induced podocyte injury (Yang et al., 2020)

GLP-1 receptor agonist (RA) medications are highly effective for managing weight and blood sugar, but they can also disrupt digestive healthleading to discomfort, irregularity, and microbial imbalance

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