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Immune system failure could lead to uncontrolled replication of the SARS-CoV-2 virus, secondary infections and continuous shedding of the virus in patients who die from COVID-19 regardless of the time passed from the start of the infection (Ruan et al., 2020

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Research has identified several natural compounds, often linked to senolytic effects, that can enhance the activity of SIRT1 and SIRT2

Neurodegenerative diseases are also often accompanied by inflammation, and when microglia are overactivated, large amounts of ROS are produced under the catalysis of NOX [14]