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Functionally, cagrilintide activates amylin receptors AMY1R, AMY2R, AMY3R and the calcitonin receptor (CTR), binding via a conserved bypass motif involving mid-segment residues (S19 P25) (Cao et al

[DOI] [PubMed] [Google Scholar] Pratley R.E., Aroda V.R., Lingvay I., Ldemann J., Andreassen C., Navarria A., Viljoen A

TMAO activated the expression of the inflammatory mediator high mobility group box 1 (HMGB1), which stimulated multiple receptors such as toll-like receptor 4 (TLR4), thus mediating extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2) and the NF-B signaling pathway (82)

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doi: 10.1016/j.jhep.2012.11.043