Jeukendrup AE, Randell R
Stucky, MD, PhD, can be reached at [email protected].
Previous studies suggest that the omega-loop is involved in induced fit phenomena in the active site ( Concerning ligands behavior in terms of its interaction with the protein we evaluated hydrogen bond occupancy (Supplementary Figures S30, 31), protein-ligand contact for all residues (Supplementary Figures S3240), and protein-ligand contact for residues that were within 5 of the ligand at some point during the MD simulation (Supplementary Figures S4149) to finally obtain the percentage frequency of interaction occurrences (Supplementary Figures S29)
[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Haeusler R.A., Hartil K., Vaitheesvaran B., Arrieta-Cruz I., Knight C.M., Cook J.R., Kammoun H.L., Febbraio M.A., Gutierrez-Juarez R., Kurland I.J., et al
The goal of chronic hepatitis B treatment is to suppress HBV viral replication, which may limit hepatitis progression and may lower the risk of some complications, such as cirrhosis or cancer (Gish 2012)