It is highly expressed in growth cones during axonal elongation, neural regeneration, and synaptic remodeling
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK as Mounjaro for the treatment of type 2 diabetes mellitus and as Zepbound for weight management in adults with obesity or overweight with weight-related comorbidities (BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity)
They are mostly injected beneath the skin (though there is an oral form available, called Rebelsus) after which they flood the body, producing much higher, more constant and long-lasting levels than it is used to with respect to natural GLP-1
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