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Storing the vial in a refrigerator also protects it from light, which can degrade the preservative and compromise the solution over time

A B12 shot is an intramuscular injection of either cyanocobalamin or methylcobalamin, two forms of Vitamin B12

PubMed Central, Konijeti, Gauree G., et al

Metabolic disturbances of a high-fat diet are dependent on APOE genotype and sex

If you have MTHFR mutations and previous poor response to cyanocobalamin supplements, you might prefer a formulation containing methylcobalamin instead