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Front Endocrinol (Lausanne) 14(12):735824 Hidayat K, Du X, Shi BM (2019) Risk of fracture with dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in real-world use: systematic review and meta-analysis of observational studies

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The single-dose trial appeared to have slightly higher exposure compared with the other trials in the dataset (although this was not statistically significant at the p = 0.01 level), indicating that a trial factor could be present