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Endometriotic implants secrete estradiol (E2) as well as prostaglandin E2 (PGE2), agents that attract macrophages (monocyte chemotactic protein 1[MCP-1]), neurotrophic peptides (nerve growth factor [NGF]), enzymes for tissue remodeling (matrix metalloproteinases [MMPs]) and tissue inhibitors of MMPs (TIMPs), and proangiogenic substances such as vascular endothelial growth factor (VEGF) and interleukin-8 (6)

doi: 10.1016/j.urology.2009.02.034 108 ComhaireFChristopheAZalataADhoogeWMahmoudADepuydtC

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136 Recent investigations have indicated that MDD is caused by increased ROS production and promotes inflammation

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