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All 411 participants treated were analysed for efficacy (full analysis set: all randomised participants who received one or more dose of the study drug and had analysable data for one or more efficacy endpoint) and safety (treated set: all randomised participants who received one or more dose of the study drug)

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The pharmacodynamic evaluations described below were in patients with type 2 diabetes mellitus who received once-weekly subcutaneous injections of placebo or semaglutide injection over 12 weeks (semaglutide injection-treated patients were started on lower dosages and then titrated up to 1 mg once weekly)

Fluorescence intensity was quantified using ImageJ