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FDA Safety Communications

[2] [14] Dehydration secondary to gastrointestinal adverse effects could potentially exacerbate MS-related fatigue and may increase risk of acute kidney injury, though this relationship has not been formally studied

He explained that the benefits need to be weighed against potential side effects, adding that investigations of side effects become especially important given the broad range of people this medicine and others like it could help

For a medication patients often take indefinitely, thats a distinction worth remembering: what a patient feels at the dinner table and what actually ends up on their plate are not always the same measurement