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Although no clinical studies have directly compared gastric emptying with long- and short-acting GLP-1RAs, their relative effects were illustrated in an animal study comparing liraglutide and exenatide, where the latter was shown to have a profound effect on gastric emptying while liraglutide had very little effect (124, 189)
Combinations of Treatment Methods As GLP-1 RA and amylin analog-induced weight loss arise from both distinct and overlapping mechanisms, the combination of GLP-1 RA and amylin RA has been shown to produce a synergistic effect [118]
In the SCALE Obesity and Prediabetes trial, adults on Saxenda lost an average of around 8% of body weight over 56 weeks
