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Data suggest that GIP worsens insulin sensitivity through effects on cytokine production [12] in adipose tissue [13]

One study found that in NRXN1 +/- human induced pluripotent stem cell (hiPSC)-derived neurons, there was a significant increase in expression of novel NRXN isoforms, coupled with a decrease in the wild-type NRXN isoform [179]

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Schaffer, S., & Kim, H

Recent studies involving newly diagnosed T2DM patients subjected to a 12-month observation period during metformin intervention have elucidated that metformin usage proves more efficacious in attenuating oxidative stress when compared to lifestyle modification alone