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A study demonstrated that naringin inhibits the mRNA expression of inflammatory cytokines, and MMPs, including MMP-1, MMP-3, MMP-9, and MMP-13, and promotes apoptosis in RA-FLS via PI3K/Akt and MAPK/ERK signaling pathways, as shown in Figure 2 [72]

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References Biswas SK, De Faria JB

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Certain nuclear receptor agonists, including constitutive androstane receptor (CAR), pregnane X receptor (PXR) and peroxisome proliferatoractivated receptor (PPAR), contribute to hepatocyte growth and proliferation by promoting the nuclear translocation of YAP