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Nonetheless, despite the protective function of IL-17, individuals receiving monoclonal antibody therapy aimed at IL-17A or its receptor for psoriasis have exhibited a heightened occurrence of Candida infections

Li Y, Dang L, Lv C, Lin B, Tao J, Yu N, Deng Y, Wang H, Kang X, Qin H, Chen R, Li J, Liang Y, Liang Y, Shi Y (2024b) The safety of ixekizumab in Chinese adults with moderate-to-severe plaque psoriasis: analyses from a prospective, single-arm, multicenter, 12-week observational study

Thank you Your baseline risk was likely higher than average due to the mutation but the surgery was a definite risk factor as well likely a combination of the two

IL18R1 has been shown to activate P65, which then translocates to the nucleus to promote the transcription of pro-inflammatory genes 32