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The pathophysiology of PD, limitations of the current treatment strategies, and the major obstacles of its therapies, including the BBB, progressive neurodegeneration, and challenges with targeting specificity are presented

Schipper, S

Some gut pathogens, such as Aquabacterium, Peptococcus , and Sphingomonas , have been associated with motor complications in PD (Qian et al., 2018)

Experimentally, when retinoic acid, the most active metabolite of vitamin A, is administered in noise-exposed mice, it protects the cochlea by reducing significantly the apoptosis of hair cells and consequently, inducing a faster recovery of the auditory thresholds when compared to untreated animals (Ahn et al., 2005, 2013

Terevalefim (ANG-3777), a small molecule hepatocyte growth factor (HGF) mimetic, induces c-MET dimerization and phosphorylation, reducing apoptosis and increasing cellular proliferation