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Studies have shown that Xiaoyao Pill upregulates the expression of DNMT1 in patients with depression, salvaging the abnormal gene expression and DNA methylation patterns associated with depression [2, 526]

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Additionally, patients with renal or hepatic impairment may have altered glutathione metabolism and require individualized dosing assessment

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Phytother Res 11(1):5456 Mukherjee S, Banerjee SK, Maulik M, Dinda AK, Talwar KK, Maulik SK (2003) Protection against acute adriamycin-induced cardiotoxicity by garlic: role of endogenous antioxidants and inhibition of TNF- expression