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This shift has opened a new frontier in medicine

Most protocols run for 48 weeks continuously

Provider and patient attitudes vary, but there exists much more reluctance to initiate pharmacotherapy for obesity than for other chronic diseases such as hypertension, type 2 diabetes, or hyperlipidemia

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This reduced effect of FMD in the P72 over the R72 group was still evident in a refeeding phase, where patients had no nutritional restrictions for 1 week after the third FMD cycle