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It can reduce the absorption of oral medications, including oral contraceptives, so additional contraceptive methods should be used for 4 weeks after starting Zepbound or after dose increases

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Additionally, PDOs have been widely used for predicting drug sensitivity in CRC and can be combined with mitochondrial function dyes (e.g., JC-1, TMRM) to perform metabolic dependency-based individual screening [178]

While described as nonselective at other melanocortin receptors, its clinical effects are predominantly MC1R-mediated