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10.1038/ncomms7201 227 RimessiA.PozzatoC.CarparelliL.RossiA.RanucciS.de FinoI.et al (2020)

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Men on clomiphene citrate reported adverse events (depressive thoughts, weak muscle strength, gynecomastia, mood changes, agitation, or changes in estradiol or hematocrit levels) 18.18% of the time compared to just 3.45% of the time for patients on enclomiphene

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Comparison of adaptive pacing therapy, cognitive behavior therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial