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However, the inhibition of -GCS activity by GSH is of physiological significance [7] and is the rate-limiting step in GSH biosynthesis

Later work examined NNMT inhibition combined with dietary changes in obese mice, reporting reductions in body weight, fat mass, and hepatic fat, alongside shifts in gut bacterial populations

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Advances in incretin-based pharmacotherapy, including glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual GLP-1/glucose-dependent insulinotropic peptide RAs, have transformed the landscape of weight-loss management

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