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Coverage decisions evolve as more clinical evidence accumulates and as employer demand for GLP-1 medications increases

The comparator groups differed among studies, with some employing placebo controls (e.g., PIONEER-6, Gerstein 2019), others using active comparators such as sitagliptin, glimepiride, DPP-4 inhibitors, or SGLT2 inhibitors, and some utilizing standard care or intensive lifestyle interventions as the control

Thyroid-Related Concerns : Although primarily observed in rodent studies, tirzepatide carries a boxed warning regarding thyroid C-cell tumors

Unlike bariatric surgery, intestinal fat absorption surfaces remain intact

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