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Inhibition of upstream activators of the JNK pathway, including kRas, Rac/cdc42 and mixed lineage kinases also provides protection to HCs (Bodmer et al., Apoptosis Following the activation of MAPK and ROS stress pathways, cochlear HCs can undergo apoptosis following intense noise exposure, aminoglycoside or cisplatin ototoxicity, or aging (Hu et al., b

The SELECT trial, published in 2023, demonstrated that semaglutide 2.4 mg (Wegovy) reduced the risk of major adverse cardiovascular events by 20% in patients with obesity and established cardiovascular disease but without diabetes

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How GLP-1 Medications Work GLP-1 receptor agonists mimic the bodys natural GLP-1 hormone, which helps signal the body to release more insulin when blood sugar is high