Natural compounds offer a promising alternative, given their ability to modulate multiple pathways simultaneously
For example, a 2007 study published in the Russian language by Korkushko et al
This highly coordinated network is dependent on: 1) the coordination and division of labor among multiple organs and cell types, such as the involvement of the liver in lipid synthesis, -oxidation, the conversion of cholesterol to bile acids, the role of adipose tissue in triglyceride (TG) storage and the thermogenesis of brown adipocytes [8]
Their influence on neuronal communication and brain homeostasis is largely exerted via gliotransmitters such as GABA, glutamate, D -serine, lactate, and ATP/adenosine, in addition to neurotrophic factors like proBDNF and BDNF
4: Sikiric P, Barisic I, Udovicic M, Lovric Bencic M, Balenovic D, Strinic D, Zivanovic Posilovic G, Uzun S, Vranes H, Krezic I, Lozic M, Stambolija V, Premuzic Mestrovic I, Beketic Oreskovic L, Oreskovic I, Strbe S, Sikiric S, Tomic L, Kordic M, Tvrdeic A, Seiwerth S, Boban Blagaic A, Skrtic A
