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(2) the estimated average reasonable cost of the devices in the category exceeds the cost of the device-related portion of the APC payment amount for the related service by at least 25 percent

The British National Formulary (BNF) states: For people with neurological involvement Initially administer hydroxocobalamin 1 mg intramuscularly on alternate days until there is no further improvement, then administer hydroxocobalamin 1 mg intramuscularly every 2 months

After several months of consistent treatment, blood tests often show lower homocysteine