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Use of synthetic IGF-1 analogs is prohibited at all times due to their performance-enhancing potential and influence on growth pathways. WADA Prohibited List, 2024 Legal Status in the United States and Globally Possession for personal research use is not criminalized in most jurisdictionsbut selling, distributing, or marketing IGF-1 peptides for human consumption can lead to regulatory penalties

Mouse models have been used to support this connection, with all listed ages below 3 months old (Worgul et al., 2002

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Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

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