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Therefore, this study provided the first evidence of functional GLP-1R expression in human iTreg cells, and suggested that GLP-1R might play a key role in the anti-inflammatory effects attributed to GLP-1RA

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Developing and refining preclinical models for early efficacy signals, developing and validating the bioanalytical assays necessary for quantitation, and designing the clinical studies that deliver the most robust data in this innovative therapeutic area are all key elements of a drug development program

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