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More likely environmental triggers

To address this, intestinal PEs based primarily on medium chain fatty acid (MCFA) structures have been investigated to transiently and reversibly increase paracellular permeability ( 10 ), for example, acts via multimodal mechanisms to enhance TJ permeability and increase mucosal uptake of peptides (Maher et al., 2023)

Both work for topical use

136.0 136.1 Carvajal RD, Sosman JA, Quevedo JF, et al

Common side effects include: Nausea and vomiting Diarrhea or constipation Stomach discomfort These symptoms often decrease over time but may require dose adjustments or temporary discontinuation